Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Abstract Background Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination.The scale of these costs is highly variable.Some, including resistance of Staphylococcus aureus to the clinically important antibiotic mupirocin, have been reported as Hair Styling Tools being cost-free, which suggest

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A comprehensive review on the application of microbially induced calcite precipitation (MICP) technique in soil erosion mitigation as a sustainable and environmentally friendly approach

Erosion is regarded as a significant global concern caused by the inferior engineering characteristics of soils, encompassing their susceptibility to collapse and high porosity as well as their limited strength.These attributes render soils prone to the adverse consequences of erosion, which can have far-reaching implications for the environment, i

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Determinants and pathways of healthcare-seeking behaviours in under-5 children for common childhood illnesses and antibiotic prescribing: a cohort study in rural India

Objectives To explore the healthcare-seeking pathways, antibiotic prescribing and determine the sociodemographic factors associated with healthcare-seeking behaviour (HSB) of caregivers for common illnesses in under-5 (U-5) children in rural Ujjain, India.Study design Prospective cohort study.Study setting and study sample The cohort included 270 U

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